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JMD 2007, Vol. 9, No. 1
Copyright © 2007 American Society for Investigative Pathology & Association for Molecular Pathology

Development of a Web-Based Query Tool for Quality Assurance of Clinical Molecular Genetic Test Results

Matthew J. McGinniss*, Rebecca Chen{dagger}, Victoria M. Pratt{ddagger}, Arlene Buller*, Franklin Quan*, Charles M. Strom*, Weimin Sun* and Beryl Crossley{ddagger}

From the Genetic Testing Center * and Advanced Diagnostics Information Technology, {dagger} Quest Diagnostics Nichols Institute, San Juan Capistrano, California; and the Department of Molecular Genetics, {ddagger} Quest Diagnostics Nichols Institute, Chantilly, Virginia

The College of American Pathologists molecular pathology checklist item (MOL.20550) calls for periodic review of molecular genetic statistics, including percentages of normal and abnormal findings and allele frequencies. A web-based query tool application for clinical molecular genetic test results was developed to plot dynamically and display genotype and/or allele frequencies for any time period. This tool is used to produce plots of all high-volume molecular genetic assays (>50 samples per month). A single web page contains pull-down menus, enabling the user to select the type of chart to be generated (genotype or allele frequency), the molecular genetic assays to chart (from one to all), the ending date for data in the chart (month and year), and the duration of the time period to plot (1 to 12 months). The rendered graphical and textual frequency data can then be viewed or printed. This tool can be used by any laboratory and interfaced with a standard laboratory information system. Monthly quality control charts and tables are now generated in minutes compared with the hours it took using manual charting applications. This simplified process enables timely compliance with a College of American Pathologists checklist item.






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Copyright © 2007 by the American Society for Investigative Pathology and the Association for Molecular Pathology.