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JMD 2002, Vol. 4, No. 4
Copyright © 2002 American Society for Investigative Pathology & Association for Molecular Pathology

Consultations in Molecular Diagnostics

Bone Marrow Transplant Engraftment Analysis with Loss of an Informative Allele

Steven A. Schichman*{dagger}, Pei Lin{dagger}, Lori J. Gilbrech*, Pamela S. Gray*, Carla S. Wilson{dagger} and Jeffrey R. Sawyer{dagger}{ddagger}

From the Pathology and Laboratory Medicine Service * Central Arkansas Veterans Healthcare System, Little Rock; the Department of Pathology {dagger} University of Arkansas for Medical Sciences, Little Rock; and the Cytogenetics Laboratory {ddagger} Arkansas Children’s Hospital Little Rock, Arkansas

Abstract

Short tandem repeats (STRs) are highly polymorphic DNA sequences in the human genome. STR genotype analysis is used for human identity testing and to monitor bone marrow engraftment after allogeneic transplantation.1 2 3 Engraftment analysis requires one or more informative STR loci that distinguish recipient from donor. The following case illustrates that chromosome loss in tumor cells during the course of disease may cause corresponding loss of an STR locus. This circumstance is a potential source of error in the interpretation of engraftment analysis, especially if only one informative allele is used to monitor engraftment.




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S. L. Swierczynski, M. J. Hafez, J. Philips, M. A. Higman, K. D. Berg, and K. M. Murphy
Bone Marrow Engraftment Analysis after Granulocyte Transfusion
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[Abstract] [Full Text] [PDF]


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