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From the Departments of Pathology and Microbiology,
*
Orthopaedic Surgery,
and Pediatrics,
Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska; the Department of Pathology,
§
Memorial Sloan-Kettering Cancer Center, New York, New York; the Departments of Pathology
¶
and Orthopaedic Surgery,
||
Shards Hospital, Gainesville, Florida; and Trinity Lutheran Hospital,
**
Kansas City, Missouri
Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.
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M. D. Camp, R. K. Tompkins, S. S. Spanier, J. A. Bridge, and C. H. Bush Best Cases from the AFIP: Adamantinoma of the Tibia and Fibula with Cytogenetic Analysis RadioGraphics, July 1, 2008; 28(4): 1215 - 1220. [Full Text] [PDF] |
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