JMD Association for Molecular Pathology 2008 Annual Meeting
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JMD 2001, Vol. 3, No. 1
Copyright © 2001 American Society for Investigative Pathology & Association for Molecular Pathology

Extra Copies of Chromosomes 7, 8, 12, 19, and 21 are Recurrent in Adamantinoma

Masahiko Kanamori*, Cristina R. Antonescu§, Melody Scott*, Robert S. Bridge, Jr.*, James R. Neff{dagger}, Suzanne S. Spanier, Mark T. Scarborough||, Gerardo Vergara**, Howard G. Rosenthal** and Julia A. Bridge*,{dagger}{ddagger}

From the Departments of Pathology and Microbiology, * Orthopaedic Surgery, {dagger} and Pediatrics, {ddagger} Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska; the Department of Pathology, § Memorial Sloan-Kettering Cancer Center, New York, New York; the Departments of Pathology and Orthopaedic Surgery, || Shards Hospital, Gainesville, Florida; and Trinity Lutheran Hospital, ** Kansas City, Missouri

Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.




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M. D. Camp, R. K. Tompkins, S. S. Spanier, J. A. Bridge, and C. H. Bush
Best Cases from the AFIP: Adamantinoma of the Tibia and Fibula with Cytogenetic Analysis
RadioGraphics, July 1, 2008; 28(4): 1215 - 1220.
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